2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10873S
    N-Desethyl Sunitinib-d5
    N-Desethyl Sunitinib-d5 is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
    N-Desethyl Sunitinib-d<sub>5</sub>
  • HY-133794S
    Dasatinib N-oxide-d8
    Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor.
    Dasatinib N-oxide-d<sub>8</sub>
  • HY-B1398S
    Ampyrone-d3
    Ampyrone-d3 is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy.
    Ampyrone-d<sub>3</sub>
  • HY-132617S
    Carboxy Gliclazide-d4
    		Modulator
    Carboxy Gliclazide-d4 is the deuterium labeled Carboxy Gliclazide.
    Carboxy Gliclazide-d<sub>4</sub>
  • HY-12784AS
    Cycloguanil-d4 hydrochloride
    Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil-d<sub>4</sub> hydrochloride
  • HY-108251S
    Methotrexate metabolite-d3
    Methotrexate metabolite-d3 is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
    Methotrexate metabolite-d<sub>3</sub>
  • HY-132286S
    2-PADQZ-d8
    2-PADQZ-d8 is the deuterium labeled 2-PADQZ-d8.
    2-PADQZ-d<sub>8</sub>
  • HY-100662S
    Didesethyl chloroquine-d4
    Didesethyl chloroquine-d4 is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant.
    Didesethyl chloroquine-d<sub>4</sub>
  • HY-12772S2
    (2R,4S)-Hydroxy Itraconazole-d5
    		99.40%
    (2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole.
    (2R,4S)-Hydroxy Itraconazole-d<sub>5</sub>
  • HY-135111S
    4-Desmethoxy Omeprazole-d3
    4-Desmethoxy Omeprazole-d3 is the deuterium labeled 4-Desmethoxy Omeprazole. 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Kiof 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
    4-Desmethoxy Omeprazole-d<sub>3</sub>
  • HY-132770S
    Propafenone Dimer Impurity-d10
    Propafenone Dimer Impurity-d10 is the deuterium labeled Propafenone Dimer Impurity.
    Propafenone Dimer Impurity-d10
  • HY-124104
    Aldicarb sulfoxide
    Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC50 of 10 μM for both in zebrafish.
    Aldicarb sulfoxide
  • HY-153408
    4-Hydroxylidocaine
    4-Hydroxylidocaine is a Lidocaine (HY-B0185) metabolite.
    4-Hydroxylidocaine
  • HY-131266R
    Febuxostat n-butyl isomer (Standard)
    Menadione bisulfite (sodium) (Standard) is the analytical standard of Menadione bisulfite (sodium). This product is intended for research and analytical applications. Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.
    Febuxostat n-butyl isomer (Standard)
  • HY-135586
    Raloxifene N-Oxide
    Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
    Raloxifene N-Oxide
  • HY-132569S
    8-Hydroxy warfarin-d5
    8-Hydroxy warfarin-d5 can be used as an internal standard for the quantification of Warfarin and its known metabolites.
    8-Hydroxy warfarin-d5
  • HY-119532R
    Nordeprenyl (Standard)
    Chromium picolinate (Standard) is the analytical standard of Chromium picolinate. This product is intended for research and analytical applications. Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.
    Nordeprenyl (Standard)
  • HY-131729
    16-Phenoxy tetranor Prostaglandin A2
    16-Phenoxy tetranor Prostaglandin A2 is a metabolite of uprostone and an analog of the antifertility hormone PGF2α.
    16-Phenoxy tetranor Prostaglandin A2
  • HY-20390S
    Lapatinib impurity 18-d4
    Lapatinib impurity 18-d4 is deuterium labeled 3-Chloro-4-((3-fluorobenzyl)oxy)aniline.
    Lapatinib impurity 18-d<sub>4</sub>
  • HY-148682R
    18β-Glycyrrhetyl-3-O-sulfate (Standard)
    (Z)-Methyl icos-11-enoate (Standard) is the analytical standard of (Z)-Methyl icos-11-enoate. This product is intended for research and analytical applications. (Z)-Methyl icos-11-enoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    18β-Glycyrrhetyl-3-O-sulfate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity