2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125780R
    5-Phenylhydantoin (Standard)
    Dasatinib (monohydrate) (Standard) is the analytical standard of Dasatinib (monohydrate). This product is intended for research and analytical applications. Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy.
    5-Phenylhydantoin (Standard)
  • HY-109564R
    5α-Pregnane-3β,6α-diol-20-one (Standard)
    Arjungenin (Standard) is the analytical standard of Arjungenin. This product is intended for research and analytical applications. Arjungenin, a triterpene isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor.
    5α-Pregnane-3β,6α-diol-20-one (Standard)
  • HY-148053R
    Rezivertinib analogue 1 (Standard)
    Rezivertinib analogue 1 (Standard) is the analytical standard of Rezivertinib analogue 1. This product is intended for research and analytical applications. Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer[1].
    Rezivertinib analogue 1 (Standard)
  • HY-155385
    10-Oxo-12(Z),15(Z)-octadecadienoic acid
    10-Oxo-12(Z),15(Z)-octadecadienoic acid is a gut microbial fatty acid metabolite.
    10-Oxo-12(Z),15(Z)-octadecadienoic acid
  • HY-133092R
    Perphenazine sulfoxide (Standard)
    Perphenazine sulfoxide (Standard) is the analytical standard of Perphenazine sulfoxide. This product is intended for research and analytical applications. Perphenazine sulfoxide is a sulphoxide metabolite of Perphenazine, formed by the oxidation of Perphenazine.
    Perphenazine sulfoxide (Standard)
  • HY-133005
    Desacetylvinblastine
    Desacetylvinblastine (4-Desacetylvinblastine) is the major metabolite of Vinblastine (HY-13780) and a cytotoxic agent. When used alone, desacetylvinblastine has poor anti-tumor effects, but it can exert significant anti-tumor activity when in the presence of specific conjugates.
    Desacetylvinblastine
  • HY-144242S
    Voriconazole EP impurity D-d3
    Voriconazole EP impurity D-d3 is the deuterium labeled Voriconazole EP impurity D.
    Voriconazole EP impurity D-d<sub>3</sub>
  • HY-W706930
    DCBA-d10
    DCBA-d10 is the deuterium labeled DCBA (HY-136612). DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
    DCBA-d<sub>10</sub>
  • HY-W766709
    Desdiacetyl bisacodyl-d13
    Desdiacetyl bisacodyl-d13 is the deuterium labeled Desacetyl bisacodyl (HY-131637). Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion.
    Desdiacetyl bisacodyl-d<sub>13</sub>
  • HY-136498AR
    T-705RMP ammonium (Standard)
    Rilmenidine (phosphate) (Standard) is the analytical standard of Rilmenidine (phosphate). This product is intended for research and analytical applications. Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .
    T-705RMP ammonium (Standard)
  • HY-12784AS1
    Cycloguanil-d6 hydrochloride
    Cycloguanil-d6 hydrochloride is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil-d<sub>6</sub> hydrochloride
  • HY-131622
    7-Aminoclonazepam
    		Control
    7-Aminoclonazepam is a major metabolite of Clonazepam that can be for the assessment of Clonazepam use.
    7-Aminoclonazepam
  • HY-133694S
    2-Aminoflubendazole-13C6
    2-Aminoflubendazole-13C6 is the 13C6 labeled 2-Aminoflubendazole. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
    2-Aminoflubendazole-<sup>13</sup>C<sub>6</sub>
  • HY-137414
    20-Hydroxy Prostaglandin E2
    20-Hydroxy Prostaglandin E2 (20-Hydroxy-PGE2) is a metabolite of Prostaglandin E2 (HY-101952) that can be metabolized by cytochrome P450.
    20-Hydroxy Prostaglandin E2
  • HY-I0678S
    Regorafénib N-oxyde-d3(M2)
    Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
    Regorafénib N-oxyde-d<sub>3</sub>(M2)
  • HY-66008S2
    N-Acetyl mesalazine-13C6
    N-Acetyl mesalazine-13C6 (N-Acetyl-5-aminosalicylic acid-13C6) is a deuterated labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer.
    N-Acetyl mesalazine-<sup>13</sup>C<sub>6</sub>
  • HY-139391
    (±)10(11)-DiHDPA
    (±)10(11)-DiHDPA is a fatty acid diol and a metabolite of epoxidized fatty acids (EpFAs).
    (±)10(11)-DiHDPA
  • HY-143985S
    Maytansinoid DM4 impurity 5-d6
    Maytansinoid DM4 impurity 5-d6 is the deuterium labeled Maytansinoid DM4 impurity 5.
    Maytansinoid DM4 impurity 5-d<sub>6</sub>
  • HY-W703632
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol is the deuterium labeled Ibuprofen alcohol (HY-131261). Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
    2-(4-Isobutylphenyl)propan-3,3,3-d<sub>3</sub>-1-ol
  • HY-169044
    (±)10,11-EDT
    (±)10,11-EDT is an oxylipin and a metabolite of Adrenic acid (HY-W013215).
    (±)10,11-EDT
Cat. No. Product Name / Synonyms Application Reactivity